Cervix cytology samples revealed increased methylation of the human markers <i><scp>FAM19A4</scp>/</i><scp><i>miR124</i>‐<i>2</i></scp> up to 8 years before adenocarcinoma

Abstract

Testing for methylation of FAM19A4/miR124-2 as a triage for HPV-positive women would be useful to identify women at risk of cancer development, especially adenocarcinoma. Further studies are needed to estimate the cost-effectiveness before introducing methylation testing in the screening program.