Erythroid Differentiation Enhances RNA Mis-Splicing in <i>SF3B1</i> -Mutant Myelodysplastic Syndromes with Ring Sideroblasts

Abstract

Ring sideroblast isolation combined with state-of-the-art multiomics identifies survival mechanisms underlying SF3B1-mutant erythropoiesis and establishes an active role for erythroid differentiation and ring sideroblasts themselves in SF3B1-mutant myelodysplastic syndrome pathogenesis.