Early Oral Antibiotic Switch in <i>Staphylococcus aureus</i> Bacteraemia: The <i>Staphylococcus aureus</i> Network Adaptive Platform (SNAP) Trial Early Oral Switch Protocol

Abstract

Recruitment is occurring in the EOS domain of the SNAP trial. As of August 2023, 21% of all SNAP participants had been randomized to the EOS domain, a total of 264 participants across 77 centers, with an aim to recruit at least 1000 participants. We describe challenges and facilitators to enrolment in this domain to aid those planning similar trials.