Prostate-Specific Membrane Antigen–Targeting Alpha Emitter via Antibody Delivery for Metastatic Castration-Resistant Prostate Cancer: A Phase I Dose-Escalation Study of <sup>225</sup>Ac-J591 - Concepedia

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Prostate-Specific Membrane Antigen–Targeting Alpha Emitter via Antibody Delivery for Metastatic Castration-Resistant Prostate Cancer: A Phase I Dose-Escalation Study of <sup>225</sup>Ac-J591

DOI Full Paper Access

60

Citations

34

References

2023

Year

Scott T. Tagawa, Charlene Thomas, Oliver Sartor, Michael Sun, Judith Stangl‐Kremser, Mahelia Bissassar, Shankar Vallabhajosula, Sandra Huicochea Castellanos, Jones T. Nauseef, Cora N. Sternberg,

Journal of Clinical Oncology

Abstract

To our knowledge, this is the first-in-human phase I dose-escalation trial of a single dose of <sup>225</sup>Ac-J591 in 32 patients with pretreated progressive mCRPC demonstrated safety and preliminary efficacy signals. Further investigation is underway.

References

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