Concepedia

Characterization and root cause analysis of immunogenicity to pasotuxizumab (AMG 212), a prostate-specific membrane antigen-targeting bispecific T-cell engager therapy

Hweixian Leong Penny, Kelly Hainline, Nathaniel Theoharis, Bin Wu, Christian Brandl, Christian Webhofer, Mason McComb, Sabine Wittemer‐Rump, Gökben Koca, Sabine Stienen,

Frontiers in Immunology · 2023 · 21 citations · 29 references

DOIFull text

Open access

Abstract

These mechanistic insights into the AMG 212 ADA response underscore the importance of performing preclinical immunogenicity risk evaluation as well as advocate for continuous iteration to better our biologics.

References

29

Design and End Points of Clinical Trials for Patients With Progressive Prostate Cancer and Castrate Levels of Testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group

Howard I. Scher, Susan Halabi, Ian F. Tannock et al. · Journal of Clinical Oncology · 2008 · 2.2K citations · Full text

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

Lawrence J. Stern, Jerry H. Brown, Theodore S. Jardetzky et al. · Nature · 1994 · 1.6K citations

, , +10

The immunogenicity of humanized and fully human antibodies

Fiona Harding, Marcia Stickler, Jennifer Razo et al. · mAbs · 2010 · 709 citations · Full text

Distinct Dendritic Cell Populations Sequentially Present Antigen to CD4 T Cells and Stimulate Different Aspects of Cell-Mediated Immunity

Andrea Itano, Stephen J. McSorley, R. Lee Reinhardt et al. · Immunity · 2003 · 697 citations · Full text

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Immunogenicity of protein therapeutics: The key causes, consequences and challenges

Matthew Baker, Helen Reynolds, Brooke Lumicisi et al. · Self/Nonself · 2010 · 349 citations · Full text

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