Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment

Dose translation from animal to human studies revisited

Shannon Reagan‐Shaw, Minakshi Nihal, Nihal Ahmad · The FASEB Journal · 2007 · 6.1K citations

Pharmacotherapy, Laboratory Animal Study, Translational Medicine +19

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

Tonghui Ma, Jay R. Thiagarajah, Hong Yang et al. · Journal of Clinical Investigation · 2002 · 631 citations · Full text

Intestinal Fluid Secretion, Fluid Secretion, Gastrointestinal Pharmacology +16

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

Tonghui Ma, Jay R. Thiagarajah, Hong Yang et al. · Journal of Clinical Investigation · 2002 · 529 citations

Intestinal Fluid Secretion, Fluid Secretion, Gastrointestinal Pharmacology +18

Pharmacodynamics of the Type II Calcimimetic Compound Cinacalcet HCl

Edward F. Nemeth, Haynes Heaton, Michael A. Miller et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 365 citations

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis

Vinita Takiar, Saori Nishio, Patricia Seo-Mayer et al. · Proceedings of the National Academy of Sciences · 2011 · 332 citations

Renal Inflammation, Cellular Physiology, Renal Function +16