Metal-free, <i>tert</i>-butyl nitrite promoted C(sp²)–S coupling reaction: the synthesis of aryl dithiocarbamates and analysis of antimicrobial activity by ‘<i>in silico</i>’ and ‘<i>in vitro</i>’ methods for drug modification

Abstract

An environmentally friendly, metal-free, and efficient C(sp 2 )–S coupling reaction protocol between aniline and low-cost tetraalkylthiuram disulfides was developed to synthesize aryl dithiocarbamates.