The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors

Microtubule Assembly in the Absence of Added Nucleotides

Michael L. Shelanski, Felicia Gaskin, Charles R. Cantor · Proceedings of the National Academy of Sciences · 1973 · 2.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8

Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[<i>b</i>]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties

Bernard L. Flynn, Gurmit S. Gill, Damian Grobelny et al. · Journal of Medicinal Chemistry · 2011 · 139 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities

Yichang Ren, Yuxi Wang, Gang Li et al. · Journal of Medicinal Chemistry · 2021 · 105 citations

Medicine, Medicinal Chemistry, Oncology +14

Optimization of 4-(<i>N</i>-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site

Xiao Feng Wang, Fang Guan, Emika Ohkoshi et al. · Journal of Medicinal Chemistry · 2014 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions

Zelleka Getahun, Leonard Jurd, Ping S. Chu et al. · Journal of Medicinal Chemistry · 1992 · 64 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13