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Effectiveness of mRNA COVID-19 Monovalent and Bivalent Vaccine Booster Doses Against Omicron Severe Outcomes Among Adults Aged ≥50 Years in Ontario, Canada: A Canadian Immunization Research Network Study

Ramandip Grewal, Sarah A. Buchan, Lena Nguyen, Sharifa Nasreen, Peter C. Austin, Kevin A. Brown, Jonathan B. Gubbay, Nelson Lee, Kevin L. Schwartz, Mina Tadrous,

The Journal of Infectious Diseases · 2023 · 17 citations · 3 references

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Abstract

We estimated the effectiveness of booster doses of monovalent and bivalent mRNA COVID-19 vaccines against Omicron-associated severe outcomes among adults aged ≥50 years in Ontario, Canada. Monovalent and bivalent mRNA COVID-19 booster doses provided similar strong initial protection against severe outcomes. Uncertainty remains around waning of protection from these vaccines.

References

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Spyros Chalkias, Charles Harper, Keith Vrbicky et al. · New England Journal of Medicine · 2022 · 649 citations · Full text

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Comparative effectiveness of bivalent BA.4-5 and BA.1 mRNA booster vaccines among adults aged ≥50 years in Nordic countries: nationwide cohort study

Niklas Worm Andersson, Emilia Myrup Thiesson, Ulrike Baum et al. · BMJ · 2023 · 80 citations · Full text

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Protection against symptomatic SARS-CoV-2 infection conferred by the Pfizer-BioNTech Original/BA.4-5 bivalent vaccine compared to the mRNA Original monovalent vaccines – A matched cohort study in France

Vincent Auvigne, Cynthia Tamandjou, Justine Schaeffer et al. · Vaccine · 2023 · 22 citations · Full text

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