Inorganic Chemistry · 2023 · 12 citations · 129 references
Natural SciencesChemistryMedicinal ChemistryComputational ChemistryDrug DiscoveryStructure-activity RelationshipsCarbene ComplexesCoordination ChemistryCrystal ChemistryLigand BindingMetal-ligand BondingTransition Metal ComplexesBioinorganic Coordination ChemistryCarbene Complex CrystallographyComplexation ChemistryElectronic Structure Of Metal ComplexesIntermolecular Metal-ligand InteractionsSingle-crystal DiffractionSingle-crystal X-ray DiffractionX-ray Diffraction Analysis
Derivatization of (NHC)M-Cl (M = Ag, Au) with selected sulfur donors from the family of dialkyldithiophosphates and bis(2-mercapto-1-methylimidazolyl)borate ligands gave a series of heteroleptic mononuclear complexes. In single-crystal X-ray diffraction analysis, Ag(I) complexes adopted a trigonal planar geometry, while Au(I) complexes are near-linear. TD-DFT and hole–electron analyses of the selected complexes gave insight into the electronic features of the metal complexes. In vitro cellular tests were conducted on the human cancerous breast cell line MCF-7 using 2 and 8 . The antibacterial activities of complexes 1, 2, 3, 7, 8, and IPr–Ag-Cl were also screened against Gram-positive ( Staphylococcus aureus PTCC 1112) and Gram-negative ( Escherichia coli PTCC 1330) bacteria. Antityrosinase and hemolytic effects of the selected compounds were also determined.
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