Recent Advancements in Typical Friedel–Crafts Alkylation Reactions Focused on Targeting Arene Nucleophiles

Abstract

Abstract This review delves into recent advances and significant breakthroughs in the field of the catalytic Friedel–Crafts alkylation of targeted arenes or heteroarenes. Though a few earlier literatures are referenced, the main emphasis of this review focuses on the literature mainly published between 2015 and March 2023. 1 Introduction 2 History and Background 3 Alcohols as Alkylating Agents 4 Aldehydes and Ketones as Alkylating Agents 5 Alkyl Fluorides as Alkylating Agents 6 Epoxides as Alkylating Agents 7 Cyclopropanes as Alkylating Agents 8 Conclusion and Outlook