High expression of P-selectin induces neutrophil extracellular traps via the PSGL-1/Syk/Ca2+/PAD4 pathway to exacerbate acute pancreatitis

Abstract

Taken together, these results suggest that P-selectin induces NETs through PSGL-1 and its downstream Syk/Ca²⁺/PAD4 signaling pathway, and that targeting this pathway might be a promising strategy for the treatment of AP.