Concepedia

Tofacitinib Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglial Polarization via JAK/STAT Signaling Pathway

Hongdao Ma, Chenfeng Wang, Lin Han, Fanqi Kong, Zhixiao Liu, Bangke Zhang, Wenxiang Chu, Haibin Wang, Liang Wang, Qisheng Li,

International Journal of Biological Sciences · 2023 · 72 citations · 36 references

DOIFull text

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Concepts

Abstract

Our study showed that TOF could regulate microglial activation via JAK / STAT pathway and promote the recovery of motor function after SCI, which is of great significance for the immunotherapy of SCI.

References

36

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Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

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Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

Victor Bellver‐Landete, Floriane Bretheau, Benoit Mailhot et al. · Nature Communications · 2019 · 653 citations · Full text

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