Tandem bispecific <scp>CD123</scp>/<scp>CLL</scp>‐1 <scp>CAR‐T</scp> cells exhibit specific cytolytic effector functions against human acute myeloid leukaemia

Abstract

CD123/CLL-1 CAR-T cells in tandem can simultaneously target CD123 and CLL-1 on AML cells, demonstrating a significant ability to kill single antigens and multi-target tumour cells. This suggests that CD123/CLL-1 CAR-T cells exhibit significant advantages in the expression of multiple antigens in a wide range of target cells, which may help overcome the challenges posed by tumour heterogeneity and evasion mechanisms.