Abnormal blood microbiota profiles are associated with inflammation and immune restoration in HIV/AIDS individuals

Abstract

The characteristics of blood microbiota in HIV-infected individuals and their relevance to disease progression are still unknown, despite alterations in gut microbiota diversity and composition in HIV-infected individuals. Here, we present evidence of increased blood microbiota diversity in HIV-infected individuals, which may result from gut microbiota translocation. Also, we identify a group of microbes, <i>Porphyromonas gingivalis</i>, <i>Prevotella</i> sp. <i>CAG:5226</i>, <i>Eubacterium</i> sp. <i>CAG:251</i>, <i>Phascolarctobacterium succinatutens</i>, <i>Anaerobutyricum hallii</i>, <i>Prevotella</i> sp. <i>AM34-19LB</i>, and <i>Phocaeicola plebeius</i>, which are linked to poor immunological recovery. This work provides a scientific foundation toward therapeutic strategies targeting blood microbiota for immune recovery of HIV infection.