Synthesis of 2-Indolyl <i>C</i>-Glycoside Neopetrosins A and C and Congeners via Ni-Catalyzed Photoreductive Cross-Coupling

Abstract

The synthesis of neopetrosins A and C, two 2-indolyl <i>C</i>-α-d-mannopyranosides, and their congeners has been realized via a direct Ni/photoredox-catalyzed reductive coupling of 3-methoxycarbonyl-2-iodo-1<i>H</i>-indoles with pyranosyl bromides.