Sudden Unexpected Death in Epilepsy and Respiratory Defects in a Mouse Model of <scp>DEPDC5</scp>‐Related Epilepsy

Abstract

Depdc5 deletion in excitatory neurons is sufficient to cause DEPDC5-related epilepsy and SUDEP. Ictal apnea and respiratory dysregulation play critical roles in SUDEP. Our study also provides a novel mouse model to investigate the underlying mechanisms of DEPDC5-related epilepsy and SUDEP. ANN NEUROL 2023;94:812-824.