27‐Hydroxycholesterol Drives the Spread of α‐Synuclein Pathology in Parkinson's Disease

Abstract

27-OHC promotes the aggregation and spread of α-Syn. Strategies aimed at inhibiting the CYP27A1-27-OHC axis may hold promise as a disease-modifying therapy to halt the progression of α-Syn pathology in PD. © 2023 International Parkinson and Movement Disorder Society.