Dual-tracer PET/CT protocol with [18F]FDG and [68Ga]Ga-FAPI-46 outperforms single-tracer PET/CT with [18F]FDG in different cancer types, resulting in larger functional and gross tumor volume

Abstract

Dual-tracer PET/CT with [¹⁸F]FDG and [⁶⁸Ga]Ga-FAPI-46 showed better visualization due to a generally higher TBR and larger FTV and GTV compared to [¹⁸F]FDG-PET/CT in several tumor entities, suggesting that [⁶⁸Ga]Ga-FAPI-46 provides added value in pretherapeutic staging.