Fndc5/irisin deficiency leads to dysbiosis of gut microbiota contributing to the depressive-like behaviors in mice

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Pontus Boström, Jun Wu, Mark P. Jedrychowski et al. · Nature · 2012 · 4.7K citations · Full text

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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Nanxin Li, Boyoung Lee, Rongjian Liu et al. · Science · 2010 · 2.9K citations · Full text

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Altered fecal microbiota composition in patients with major depressive disorder

Hai‐yin Jiang, Yonghua Zhang, Hongjin Mao et al. · Brain Behavior and Immunity · 2015 · 2.3K citations · Full text

Life Sciences, Microbiology, Psychiatry +16

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

Peng Zheng, Benhua Zeng, Chunjiang Zhou et al. · Molecular Psychiatry · 2016 · 2.1K citations

Life Sciences, Microbiology, Psychiatry +16

Depression Is the Leading Cause of Disability Around the World

Michael Friedrich · JAMA · 2017 · 1.5K citations

Medicine, Neurology, Otolaryngology +5