Single-cell Profiling Uncovers a <i>Muc4</i> -Expressing Metaplastic Gastric Cell Type Sustained by <i>Helicobacter pylori</i> -driven Inflammation

Abstract

Using a mouse model, we have delineated metaplastic pit cells as a precancerous cell type whose expansion requires <i>Hp</i>-driven inflammation. In humans, metaplastic pit cells show enhanced proliferation as well as enrichment in precancer and early cancer tissues, highlighting an early step in the gastric metaplasia to cancer cascade.