Concepedia

Hemophagocytic lymphohistiocytosis–like hyperinflammation due to a de novo mutation in DPP9

Christine Wolf, Hannah Fischer, Jörn‐Sven Kühl, Sarah Koss, Rami Abou Jamra, Sven Starke, Jurek Schultz, Stephan Ehl, Katrin Neumann, Catharina Schuetz,

Journal of Allergy and Clinical Immunology · 2023 · 13 citations · 10 references

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References

10

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

Franklin L. Zhong, Ons Mamaï, Lorenzo Sborgi et al. · Cell · 2016 · 429 citations · Full text

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Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding

Franklin L. Zhong, Kim S. Robinson, Daniel Eng Thiam Teo et al. · Journal of Biological Chemistry · 2018 · 250 citations · Full text

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DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation

Louis Hollingsworth, Humayun Sharif, Andrew R. Griswold et al. · Nature · 2021 · 199 citations · Full text

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CARD8 inflammasome activation triggers pyroptosis in human T cells

Andreas Linder, Stefan Bauernfried, Yiming Cheng et al. · The EMBO Journal · 2020 · 190 citations · Full text

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Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

Menghang Huang, Xiaoxiao Zhang, Gee Ann Toh et al. · Nature · 2021 · 142 citations · Full text

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