Concepedia

Publication | Open Access

LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress

DOIFull Paper Access

18

Citations

30

References

2023

Year

Hongyang Huang, Yu‐Man Tsui, Daniel Wai‐Hung Ho, Clive Yik‐Sham Chung, Karen Man‐Fong Sze, Eva Lee, Gary Cheuk-Hang Cheung, Xin Zhang, Xia Wang, Xueying Lyu,
Hepatology

Abstract

Our data showed that LANCL1 is a cell surface protein and a key contributor to HCC initiation. Targeting the LANCL1-FAM49B-Rac1-NADPH oxidase-ROS signaling axis may be a promising therapeutic strategy for HCC.

References

YearCitations

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