Sertraline Has Fungicidal Activity Against <i>Candida</i> Spp. and Acts by Inhibiting Membrane and Cell Wall Biosynthesis

Abstract

<b>Aim:</b> Our study evaluated the activity of sertraline (SER) alone and associated with antifungal drugs in planktonic <i>Candida</i> spp. strains, and investigated its mechanism of action. <b>Materials & methods:</b> Broth microdilution method and minimum fungicidal concentration/MIC ratio were used to assess SER anticandidal activity, and the interaction with antifungals was determined by fractional inhibitory concentration index. The mechanism of action was investigated by flow cytometry and <i>in silico</i> tests. <b>Results:</b> SER inhibited <i>Candida</i> spp. strains at low concentrations by the fungicidal effect and showed no loss of effectiveness when combined. Its action seemed to be related to the membrane and cell wall biosynthesis inhibition. <b>Conclusion:</b> SER has activity against <i>Candida</i> spp. isolated and associated with antifungals, and acts by causing cell wall and membrane damage.