Xiaobanxia decoction alleviates chemotherapy-induced nausea and vomiting by inhibiting GSDME-mediated pyroptosis

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations

Life Sciences, Immunology, Molecular Biology +14

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi et al. · Nature · 2017 · 3.2K citations

Life Sciences, Cell Biology, Oncology +13

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

Junhui Yu, Shan Li, Jie Qi et al. · Cell Death and Disease · 2019 · 491 citations · Full text

Medicine, Oncology, Pharmacology +17

Nonsyndromic hearing impairment is associated with a mutation in DFNA5

Lut Van Laer, E. H. Huizing, Margriet Verstreken et al. · Nature Genetics · 1998 · 391 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

Lei Hu, Meng Chen, Xueran Chen et al. · Cell Death and Disease · 2020 · 328 citations · Full text

Life Sciences, Oncology, Pharmacology +17