Curcumin Combining Temozolomide Formed Localized Nanogel for Inhibition of Postsurgical Chemoresistant Glioblastoma

Abstract

<b>Aim:</b> To investigate the use of nanoparticle (NP)-encapsulated injectable thermosensitive hydrogel-formed nanogel for inhibition of postsurgical residual temozolomide (TMZ)-resistant glioblastoma (GBM) recurrence. <b>Materials & methods:</b> Curcumin (Cur) was coloaded with TMZ into PEG-PLGA NPs, then NPs were further encapsulated into a thermosensitive hydrogel to form a nanogel, which was injected into the resection cavity of the GBM postsurgery. <b>Results:</b> The prepared nanogel displayed excellent drug-loading capacity and long-term drug release. Estimated survival characteristics demonstrated that the nanogel could play a significant role in TMZ-resistant tumor inhibition with low drug-induced toxicity. The originally designed ratio of Cur/TMZ was sustained, making it an effective therapeutic outcome. <b>Conclusion:</b> Cur-combined TMZ-formed nanogels can be a promising candidate for the local inhibition of GBM recurrence.