Concepedia

Metformin Reduces Bone Resorption in Apical Periodontitis Through Regulation of Osteoblast and Osteoclast Differentiation

Chi‐Yuan Hong, Sze‐Kwan Lin, Han-Wei Wang, Chia‐Tung Shun, Cheng-Ning Yang, Eddie Hsiang‐Hua Lai, Shih‐Jung Cheng, Mu‐Hsiung Chen, Hsiang Yang, Hung‐Ying Lin,

Journal of Endodontics · 2023 · 16 citations · 25 references

DOI

Concepts

References

25

Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells

Gianluca D’Ippolito, Sylma Diabira, Guy A. Howard et al. · Bone · 2006 · 381 citations

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Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression

Ippei Kanazawa, Toru Yamaguchi, Shozo Yano et al. · Biochemical and Biophysical Research Communications · 2008 · 231 citations

, , +15

Metformin stimulates osteoprotegerin and reduces RANKL expression in osteoblasts and ovariectomized rats

Qiguang Mai, Zhongmin Zhang, Song Xu et al. · Journal of Cellular Biochemistry · 2011 · 227 citations

, , +17

Metformin induces osteoblast differentiation via orphan nuclear receptor SHP-mediated transactivation of Runx2

Won Gu Jang, Eun‐Jung Kim, In-Ho Bae et al. · Bone · 2010 · 192 citations

, , +14

AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts

Young‐Sun Lee, Yang-Soon Kim, Sun-Young Lee et al. · Bone · 2010 · 152 citations

, , +14