Concepedia

Discovery of blood-brain barrier permeable and orally bioavailable caffeine-based amide derivatives as acetylcholinesterase inhibitors

Mohit Sharma, Ankita Sharma, Shikha Thakur, Vijay K. Nuthakki, Ashiya Jamwal, Utpal Nandi, Hemant R. Jadhav, Sandip B. Bharate

Bioorganic Chemistry · 2023 · 12 citations · 23 references

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<scp>2021</scp> Alzheimer's disease facts and figures

Alzheimer s & Dementia · 2021 · 2.2K citations

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Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase

Miroslav Pohanka, Petr Dobeš · International Journal of Molecular Sciences · 2013 · 120 citations · Full text

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The Medicinal Chemistry of Caffeine

Giuseppe Faudone, Silvia Arifi, Daniel Merk · Journal of Medicinal Chemistry · 2021 · 116 citations · Full text

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Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT 6 receptor antagonists. Design, synthesis and biological evaluation

Anna Więckowska, Marcin Kołaczkowski, Adam Bucki et al. · European Journal of Medicinal Chemistry · 2016 · 87 citations · Full text

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Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin

Jin Wang, Zhimin Wang, Xuemei Li et al. · Bioorganic & Medicinal Chemistry · 2016 · 75 citations · Full text

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