Concepedia

Osteoclast-Derived Exosomal miR-5134-5p Interferes with Alveolar Bone Homeostasis by Targeting the JAK2/STAT3 Axis

Lai Pan, Chenyi Zhang, Haizheng Zhang, Ting Ke, Mengyao Bian, Yuxuan Yang, Lili Chen, Jingyi Tan

International Journal of Nanomedicine · 2023 · 16 citations · 27 references

DOIFull text

Open access

Abstract

Osteoclast-derived exosomal miR-5134-5p inhibits osteoblastic proliferation and differentiation via the JAK2/STAT3 pathway. OC-Exos exacerbate periodontal tissue inflammation and accelerate alveolar bone resorption in mice with experimental periodontitis.

References

27

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Defang Li, Jin Liu, Baosheng Guo et al. · Nature Communications · 2016 · 579 citations · Full text

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

Weijia Sun, Chenyang Zhao, Yuheng Li et al. · Cell Discovery · 2016 · 296 citations · Full text

Guidelines for the ethical review of laboratory animal welfare People’s Republic of China National Standard GB/T 35892‐2018 [Issued 6 February 2018 Effective from 1 September 2018]

Judy A. MacArthur Clark, Sun Deming · Animal Models and Experimental Medicine · 2020 · 193 citations · Full text

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

Rodrigo Coutinho de Almeida, Y.F. Ramos, Ahmed Mahfouz et al. · Annals of the Rheumatic Diseases · 2019 · 179 citations · Full text

Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation

Andrea E. Morrell, Genevieve Brown, Samuel T. Robinson et al. · Bone Research · 2018 · 173 citations · Full text