Safety and efficacy of human platelet extract in skin recovery after fractional CO₂ laser resurfacing of the face: A randomized, controlled, evaluator‐blinded pilot study

Abstract

Abstract Background Fractional carbon dioxide (CO 2 ) laser resurfacing is used successfully for facial rejuvenation. Post procedure skincare is a variable that influences downtime caused by pain/tenderness, erythema, crusting, and bruising. Aims The primary objective of this pilot study was to demonstrate the benefits of human platelet extract (HPE) (plated)™ CALM Serum, a new topical cosmetic product, following fractionated CO 2 ablative laser resurfacing treatment to the entire face versus standard of care. Methods In a single‐center, randomized, evaluator‐blinded pilot study, a total of 18 subjects were randomized into two groups, CO 2 facial resurfacing followed by post‐procedural standard of care (Stratacel silicone gel) or CO 2 facial resurfacing with the addition of HPE renewosomes in the CALM Serum. Results CALM Serum demonstrated statistically significant less crusting at Day 10 compared to the control group ( p = 0.0193) with less downtime in the first 14 days ( p = 0.03). Subjects treated with CALM Serum had statistically significant brighter appearing skin at 14 days ( p = 0.007) and more youthful looking skin on Days 14 and 30 ( p = 0.003 and 0.04, respectively). Conclusions This study demonstrates that Renewosome™ technology provides statistically significant post‐laser clinical recovery over silicone gel for reducing crusting, and downtime. Subjects reported less diary days of symptoms of pain/tenderness, redness, crusting/flaking, bruising, and itching in the first 14 days compared to the control group. CALM also demonstrated statistically significant improvements in brighter and more youthful appearing skin. CALM is safe and well tolerated.