Concepedia

The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation

Yu Zhong, Tong Huang, Jiewen Huang, Guomei Su, Zhilin Xiong, Yingying Lv, Shihai Li, Xianwen Lai, Yuanyuan Xiang, Qu Wang,

Theranostics · 2023 · 80 citations · 27 references

DOIFull text

Open access

Concepts

Abstract

Our results revealed that HDAC10-STAT3 interaction governs macrophage polarization to promote airway inflammation in asthma, implicating HDAC10 as a therapeutic target.

References

27

Histone Acetylase and Deacetylase Activity in Alveolar Macrophages and Blood Mononocytes in Asthma

Borja G. Cosío, Buphinder Mann, Kazuhiro Ito et al. · American Journal of Respiratory and Critical Care Medicine · 2004 · 260 citations

, , +13

The basic immunology of asthma

Hamida Hammad, Bart N. Lambrecht · Cell · 2021 · 235 citations · Full text

, , +11

MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program

Yi Wang, Lei Zhang, Guorao Wu et al. · Science Advances · 2021 · 232 citations · Full text

, , +17

Histone deacetylase 10 promotes autophagy-mediated cell survival

Ina Oehme, Jan-Peter Linke, Barbara C. Böck et al. · Proceedings of the National Academy of Sciences · 2013 · 217 citations · Full text

, , +17

VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism

Jialin Li, Bo Diao, Sheng Guo et al. · Nature Communications · 2017 · 187 citations · Full text

, , +17