Theranostics · 2023 · 33 citations · 34 references
MedicineCancer BiologyOncologyAutophagyMolecular OncologyRadiobiologyAutophagy In CancerBrain TumorsGlioblastomaGlioma RadiotherapyMolecular Tumor ProfilingRadiation TherapyAutophagy ImpairmentAutophagy-mediated RadioresistanceCancer-associated AutophagyGlioblastoma Therapeutic ResistancePrimary Brain NeoplasmsProteomic Data AnalysisRadiation Stress ResponsesTandem Mass Tag Quantification
The SDC1-TGM2-FLOT1-BHMT copolymer, a novel member of the protein complexes involved in the fusion of lysosomes and autophagosomes, maintained the autophagic flux in the irradiated tumor cells and ultimately enhanced radioresistance of GBM, which provides new insights of the molecular mechanism and therapeutic targets of radioresistant GBM.
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Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I
Keisuke Yamamoto, Anthony Venida, Julian Yano et al. · Nature · 2020 · 1.2K citations · Full text