Prognostic value of complement serum C3 level and glomerular C3 deposits in anti-glomerular basement membrane disease

Abstract

In patients with anti-GBM disease, a low serum C3 level and the presence of C3 glomerular deposits were associated with more severe disease and histological kidney involvement at diagnosis. In patients not on dialysis at diagnosis, the presence of C3 deposits was associated with worse kidney survival.