Concepedia

Inhibition of lactate transport by MCT-1 blockade improves chimeric antigen receptor T-cell therapy against B-cell malignancies

Ernesto López, Rajesh Karattil, Francesco Nannini, Gordon Weng-Kit Cheung, Lilian Denzler, Felipe Gálvez‐Cancino, Sergio A. Quezada, Martin Pulé

Journal for ImmunoTherapy of Cancer · 2023 · 46 citations · 42 references

DOIFull text

Open access

Abstract

This work highlights the potential of selective targeting of lactate metabolism via MCT-1 in combination with CAR T cells therapies against B-cell malignancies.

References

42

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

Sattva S. Neelapu, Frederick L. Locke, Nancy L. Bartlett et al. · New England Journal of Medicine · 2017 · 5.7K citations · Full text

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Stephen J. Schuster, Michael Bishop, Constantine S. Tam et al. · New England Journal of Medicine · 2018 · 3.9K citations · Full text

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

Oscar R. Colegio, Ngoc-Quynh Chu, Alison L. Szabo et al. · Nature · 2014 · 2.8K citations · Full text

, , +6

Inhibitory effect of tumor cell–derived lactic acid on human T cells

Karin Fischer, Petra Hoffmann, Simon Voelkl et al. · Blood · 2007 · 1.8K citations · Full text

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

Almut Brand, Katrin Singer, Gudrun E. Koehl et al. · Cell Metabolism · 2016 · 1.8K citations · Full text

, , +10