Concepedia

Publication | Open Access

Tetranuclear Ru<sub>2</sub>Cu<sub>2</sub> and Ru<sub>2</sub>Ni<sub>2</sub> complexes with nanomolar anticancer activity

DOIFull Paper Access

11

Citations

25

References

2023

Year

Andrés Alguacil, Franco Scalambra, Pablo Lorenzo‐Luis, Adrián Puerta, Aday González‐Bakker, Zenaida Mendoza, José M. Padrón, Antonio Romerosa
Dalton Transactions

Abstract

Complexes [{RuCp(PPh<sub>3</sub>)<sub>2</sub>-μ-dmoPTA-1κ<i>P</i>:2κ<sup>2</sup>-<i>N</i>,<i>N</i>'-CuCl}<sub>2</sub>-μ-Cl-μ-OCH<sub>3</sub>](CF<sub>3</sub>SO<sub>3</sub>)<sub>2</sub>·(CH<sub>3</sub>OH)<sub>4</sub> (1) and [{RuCp(PPh<sub>3</sub>)<sub>2</sub>-μ-dmoPTA-1κ<i>P</i>:2κ<sup>2</sup>-<i>N</i>,<i>N</i>'-NiCl}<sub>2</sub>-μ-Cl-μ-OH](CF<sub>3</sub>SO<sub>3</sub>)<sub>2</sub> (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI<sub>50</sub> values. The effects of 1 and 2 on SW1573 cells colony formation, HeLa cells action mechanism and their interaction with the pBR322 DNA plasmid were evaluated.

References

YearCitations

Page 1