The Quality of Life after Lymphaticovenous Anastomosis in 118 Lower Limb Lymphedema Patients

Abstract

<b>Background</b> This is a prospective study on 118 patients who underwent lymphaticovenous anastomosis (LVA) due to secondary lower limb lymphedema between January 2018 and October 2020 to evaluate patients' quality of life (QOL) using the Quality of Life Measure for Limb Lymphedema (LYMQoL) questionnaire. <b>Methods</b> The outcome measurement included the LYMQoL leg scoring system tool evaluating the function, appearance, symptom, mood, and overall outcome. In addition, correlation analysis was performed for three factors: based on International Society of Lymphology (ISL) stages, disease duration, and amount of volume reduction. <b>Results</b> The LYMQoL tool overall satisfaction score significantly increased at all intervals from 4.4 ± 0.2 preoperative to 6.5 ± 0.3 postoperative at 12 months ( <i>p</i> < 0.001). Significant findings were seen for each domain scores compared preoperatively and at 12 months: function score (18.6 ± 0.5 to 15.4 ± 0.6), appearance score (17.8 ± 0.5 to 16.0 ± 0.6), symptom score (11.8 ± 0.3 to 8.9 ± 0.4), and mood score (14.5 ± 0.4 to 11.4 ± 0.5; <i>p</i> < 0.05). The correlation analysis between improvement of the overall score and the ISL stage ( <i>p</i> = 0.610, correlation coefficient [ <i>r</i> ] = - 0.047), disease duration ( <i>p</i> = 0.659, <i>r</i> = - 0.041), and amount of limb volume reduction ( <i>p</i> = 0.454, <i>r</i> = - 0.070) showed no statistical significance. <b>Conclusion</b> The QOL of secondary lower limb lymphedema patients was significantly improved after LVA regardless of the severity of disease, duration of disease, and amount of volume reduction after LVA. Understanding the patient-reported outcome measurement will help the surgeons to manage and guide the expectations of the patients.