Indoxyl sulfate inhibits muscle cell differentiation via <i>Myf6</i>/MRF4 and MYH2 downregulation

Abstract

In conclusion, IS inhibits Myf6/MRF4 and MYH2 expression during differentiation of muscle cells, which could lead to a defect in myotube structure. Through these new mechanisms, IS could participate in muscle atrophy observed in CKD.