Lactate secreted by esophageal cancer cells induces <scp>M2</scp> macrophage polarization via the <scp>AKT</scp>/<scp>ERK</scp> pathway

Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer

Pieter van Hagen, Maarten C.C.M. Hulshof, J. Jan B. van Lanschot et al. · New England Journal of Medicine · 2012 · 5.3K citations · Full text

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

Oscar R. Colegio, Ngoc-Quynh Chu, Alison L. Szabo et al. · Nature · 2014 · 2.8K citations · Full text

Inflammation, Lacrimal Gland, Immunology +6

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.

Stefan Walenta, Michael Wetterling, Michael Lehrke et al. · PubMed · 2000 · 825 citations

High Lactate Levels, Tumor Recurrence, Cancer Management +19

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

Jingqi Chen, Yandan Yao, Chang Gong et al. · Cancer Cell · 2011 · 649 citations · Full text

Breast Oncology, Medicine, Immunology +6

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

Xianmin Mu, Wei Shi, Yue Xu et al. · Cell Cycle · 2018 · 478 citations · Full text

Breast Oncology, Signaling Pathway, Cell Signaling +14