The natural flavonoid compound deguelin suppresses sperm (Sus Scrofa) functions through abnormal activation of the PI3K/AKT pathway

Phosphorylation of the PTEN Tail Regulates Protein Stability and Function

Francisca Vázquez, Shivapriya Ramaswamy, Noriaki Nakamura et al. · Molecular and Cellular Biology · 2000 · 781 citations

Life Sciences, Biochemistry, Molecular Biology +17

The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus

Josema Torres, Rafael Pulido · Journal of Biological Chemistry · 2001 · 628 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Effects of Deguelin on the Phosphatidylinositol 3-Kinase/Akt Pathway and Apoptosis in Premalignant Human Bronchial Epithelial Cells

Kyung‐Hee Chun, Jerome W. Kosmeder, Shi‐Yong Sun et al. · JNCI Journal of the National Cancer Institute · 2003 · 257 citations

Medicine, Oncology, Pharmacology +16

Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa

Adam J. Koppers, Lisa A. Mitchell, Ping Wang et al. · Biochemical Journal · 2011 · 250 citations

Life Sciences, Cell Biology, Molecular Biology +17

Therapeutic Targeting of Cancers with Loss of PTEN Function

Lloye M. Dillon, Todd W. Miller · Current Drug Targets · 2014 · 250 citations

Medicine, Cancer Biology, Oncology +17