Brucella abortus modulates macrophage polarization and inflammatory response by targeting glutaminases through the NF-κB signaling pathway

Abstract

Taken together, our study demonstrates that <i>B. abortus</i> infection can induce dynamic transformation of M1/M2 phenotype in macrophages. Highlighting NF-κB as a central pathway that regulates M1/M2 phenotypic transition. This is the first to elucidate the molecular mechanism of <i>B. abortus</i> regulation of macrophage phenotype switch and inflammatory response by regulating the key gene <i>Gls</i>, which is regulated by the transcription factor NF-κB.