High density and proximity of <scp>CD8</scp>⁺<scp>T</scp> cells to tumor cells are correlated with better response to nivolumab treatment in metastatic pleural mesothelioma

Abstract

High density and spatial proximity of CD8⁺ T cells to tumor cells were associated with better response to nivolumab, whereas the proximity of regulatory T cells to tumor cells was associated with worse response, suggesting that the distinct landscape of the TME could be a potential predictor of ICI efficacy in pleural mesothelioma.