Concepedia

Mesenchymal stem cells‐derived <scp>IL</scp>‐6 promotes invasion and metastasis of oral squamous cell carcinoma via <scp>JAK‐STAT3</scp> signalling

Chuanxia Liu, Jinhan Zhou, Shanshan Zhang, Ji Fu, Yining Li, Yilong Hao, Yuan Jian, Fan Tang, Weili Ge, Hong He,

Oral Diseases · 2023 · 13 citations · 30 references

DOI

Abstract

The results indicated that MSCs-derived IL-6-promoted tumour invasion and metastasis via JAK-STAT3 signalling. Blockade of this pathway by tocilizumab may be a potential treatment to improve the prognosis and survival rate of patients with OSCC.

References

30

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians · 2018 · 86.6K citations · Full text

Cancer statistics, 2019

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2019 · 20.7K citations · Full text

, , +19

RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow

Yuehua Jiang, Balkrishna Jahagirdar, R. Lee Reinhardt et al. · Nature · 2002 · 5.5K citations

, , +12

Cancer statistics for the year 2020: An overview

Jacques Ferlay, Murielle Colombet, Isabelle Soerjomataram et al. · International Journal of Cancer · 2021 · 5.4K citations · Full text

, , +21

The MSC: An Injury Drugstore

Arnold I. Caplan, Diego Correa · Cell stem cell · 2011 · 1.6K citations · Full text

, , +6