Concepedia

Ultrasound-triggered <i>in situ</i> gelation with ROS-controlled drug release for cartilage repair

Shunli Wu, Hao Zhang, Sicheng Wang, Jinru Sun, Yan Hu, Han Liu, Jinlong Liu, Xiao Chen, Fengjin Zhou, Long Bai,

Materials Horizons · 2023 · 77 citations · 33 references

DOI

Concepts

Abstract

A novel strategy to prepare an in situ nanocomposite FLPKT hydrogel is proposed, in which ultrasound-triggered in situ gelation using ROS is a regulatory mechanism. Moreover, ROS generation and KGN release effectively improved cartilage regeneration.

References

33

miR‐23a‐3p‐abundant small extracellular vesicles released from Gelma/nanoclay hydrogel for cartilage regeneration

Hongxing Hu, Lanlan Dong, Ziheng Bu et al. · Journal of Extracellular Vesicles · 2020 · 319 citations · Full text

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mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis

Ramiro Iglesias‐Bartolomé, Vyomesh Patel, Ana P. Cotrim et al. · Cell stem cell · 2012 · 292 citations · Full text

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Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration

Dongquan Shi, Xingquan Xu, Yanqi Ye et al. · ACS Nano · 2016 · 268 citations

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Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

Caifeng Deng, Quan Zhang, Penghui He et al. · Nature Communications · 2021 · 241 citations · Full text

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A plant-derived natural photosynthetic system for improving cell anabolism

Pengfei Chen, Xin Liu, Chenhui Gu et al. · Nature · 2022 · 235 citations · Full text

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