Aging affects GABAergic function and calcium homeostasis in the mammalian central clock

Abstract

We found that the amount of GABAergic excitation was increased, and that concordantly the E/I balance was higher in SCN slices of old mice when compared to young controls. Moreover, we showed an effect of aging on the baseline intracellular Ca²⁺ concentration, with higher Ca²⁺ levels in SCN neurons of old mice, indicating an alteration in Ca²⁺ homeostasis in the aged SCN. We conclude that the change in GABAergic function, and possibly the Ca²⁺ homeostasis, in SCN neurons may contribute to the altered synchrony within the aged SCN network.