Rheumatoid Arthritis–Specific Autoimmunity in the Lung Before and at the Onset of Disease

Abstract

T cell-driven B cell differentiation resulting in local class switching and somatic hypermutation are evident in lungs before as well as in early stages of ACPA+ RA. Our findings add to the notion of lung mucosa being a site for initiation of citrulline autoimmunity preceding seropositive RA.