Nasal administration of recombinant <i>Neospora caninum</i> secreting IL-15/IL-15Rα inhibits metastatic melanoma development in lung

Abstract

Administration of IL-15/IL-15Rα-secreting <i>N. caninum</i> through intranasal administration, a non-invasive route, lend further support to <i>N. caninum</i>-demonstrated clear potential as an effective and safe immunotherapeutic approach for the treatment of metastatic solid cancers, whose existing therapeutic options are scarce. Combination of this armed protozoa with an intranasal route could reinforce the existing therapeutic arsenal against cancer and narrow the spectrum of incurable cancers.