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Publication | Open Access

ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote Colorectal Cancer and Is a Target for Boosting Immunotherapy

DOIFull Paper Access

142

Citations

31

References

2023

Year

Jianning Zhai, Huarong Chen, Chi Chun Wong, Yao Peng, Hongyan Gou, Jingwan Zhang, Yasi Pan, Danyu Chen, Yufeng Lin, Shiyan Wang,
Gastroenterology

Abstract

This study identified an ALKBH5-N<sup>6</sup>-methyladenosine-AXIN2-Wnt-DKK1 axis in CRC, which drives immune suppression to facilitate tumorigenesis. Targeting of ALKBH5 is a promising strategy for sensitizing CRC to immunotherapy.

References

YearCitations

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