Retinal arterial Aβ₄₀ deposition is linked with tight junction loss and cerebral amyloid angiopathy in MCI and AD patients

Abstract

We uncovered deficiencies in blood-retinal barrier markers for potential retinal imaging targets of AD screening and monitoring. Intense retinal arteriolar Aβ₄₀ deposition suggests a common pathogenic mechanism of failed Aβ clearance via intramural periarterial drainage.