BanXiaXieXin decoction treating gastritis mice with drug-resistant <i>Helicobacter pylori</i> and its mechanism

Abstract

BXXXT aqueous extract could demonstrate good therapeutic effects on drug-resistance <i>H. pylori in vitro</i> and <i>in vivo</i> and its mechanism comes down to the synergistic or additional antibacterial effects of berberine, emodin and luteolin, the main components of the extract; the extract could activate the immune function and enhance bactericidal effects; BXXXT aqueous extract, with main targets of BXXXT aqueous extract related to urease, virulence factors, <i>etc</i>., could reduce the urease and virulence of <i>H. pylori</i>, weaken its colonization, and reduce its inflammatory damage to the gastric mucosa.