Polysaccharides from sea buckthorn (<i>Hippophae rhamnoides L</i>.) berries ameliorate cognitive dysfunction in <scp>AD</scp> mice induced by a combination of <scp>d</scp>‐gal and <scp>AlCl₃</scp> by suppressing oxidative stress and inflammation reaction

Abstract

On the whole, these findings revealed that HRPI could improve the learning and memory ability and attenuate pathologic impairment in AD mice, and the underlying mechanisms may involve mediating oxidative stress and inflammation, possibly through the regulation of the Keap1/Nrf2 and TLR4/MyD88 signaling pathways. © 2023 Society of Chemical Industry.